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How Abilify Works, And Why It Matters

One lament of many in the mental health profession (psychiatrists and pharmascolds alike) is that we really don’t know enough about how our drugs work.  Sure, we have hypothetical mechanisms, like serotonin reuptake inhibition or NMDA receptor antagonism, which we can observe in a cell culture dish or (sometimes) in a PET study, but how these mechanisms translate into therapeutic effect remains essentially unknown.

As a clinician, I have noticed certain medications being used more frequently over the past few years.  One of these is Abilify (aripiprazole).  I’ve used Abilify for its approved indications—psychosis, acute mania, maintenance treatment of bipolar disorder, and adjunctive treatment of depression.  It frequently (but not always) works.  But I’ve also seen Abilify prescribed for a panoply of off-label indications: “anxiety,” “obsessive-compulsive behavior,” “anger,” “irritability,” and so forth.  Can one medication really do so much?  And if so, what does this say about psychiatry?

From a patient’s perspective, the Abilify phenomenon might best be explained by what it does not do.  If you ask patients, they’ll say that—in general—they tolerate Abilify better than other atypical antipsychotics.  It’s not as sedating as Seroquel, it doesn’t cause the same degree of weight gain as Zyprexa, and the risk of contracting uncomfortable movement disorders or elevated prolactin is lower than that of Risperdal.  To be sure, many people do experience side effects of Abilify, but as far as I can tell, it’s an acceptable drug to most people who take it.

Abilify is a unique pharmacological animal.  Like other atypical antipsychotics, it binds to several different neurotransmitter receptors; this “signature” theoretically accounts for its therapeutic efficacy and side effect profile.  But unlike others in its class, it doesn’t block dopamine (specifically, dopamine D2) or serotonin (specifically, 5-HT1A) receptors.  Rather, it’s a partial agonist at those receptors.  It can activate those receptors, but not to the full biological effect.  In lay terms, then, it can both enhance dopamine and serotonin signaling where those transmitters are deficient, and inhibit signaling where they’re in excess.

Admittedly, that’s a crude oversimplification of Abilify’s effects, and an inadequate description of how a “partial agonist” works.  Nevertheless, it’s the convenient shorthand that most psychiatrists carry around in their heads:  with respect to dopamine and serotonin (the two neurotransmitters which, at least in the current vernacular, are responsible for a significant proportion of pathological behavior and psychiatric symptomatology), Abilify is not an all-or-none drug.  It’s not an on-off switch. It’s more of a “stabilizer,” or, in the words of Stephen Stahl, a “Goldilocks drug.”

Thus, Abilify can be seen, at the same time, as both an antipsychotic, and not an antipsychotic.  It’s both an antidepressant, and not an antidepressant.  And when you have a drug that is (a) generally well tolerated, (b) seems to work by “stabilizing” two neurotransmitter systems, and (c) resists conventional classification in this way, it opens the floodgates for all sorts of potential uses in psychiatry.

Consider the following conditions, all of which are subjects of Abilify clinical trials currently in progress (thanks to clinicaltrials.gov):  psychotic depression; alcohol dependence; “aggression”; improvement of insulin sensitivity; antipsychotic-induced hyperprolactinemia; cocaine dependence; Tourette’s disorder; postpartum depression; methamphetamine dependence; obsessive-compulsive disorder (OCD); late-life bipolar disorder; post-traumatic stress disorder (PTSD); cognitive deficits in schizophrenia; alcohol dependence; autism spectrum disorders; fragile X syndrome; tardive dyskinesia; “subsyndromal bipolar disorder” (whatever that is) in children; conduct disorder; ADHD; prodromal schizophrenia; “refractory anxiety”; psychosis in Parkinson’s disease; anorexia nervosa; substance-induced psychosis; prodromal schizophrenia; trichotillomania; and Alzheimers-related psychosis.

Remember, these are the existing clinical trials of Abilify.  Each one has earned IRB approval and funding support.  In other words, they’re not simply the fantasies of a few rogue psychiatrists; they’re supported by at least some preliminary evidence, or at least a very plausible hypothesis.  The conclusion one might draw from this is that Abilify is truly a wonder drug, showing promise in nearly all of the conditions we treat as psychiatrists.  We’ll have to wait for the clinical trial results, but what we can say at this point is that a drug which works as a “stabilizer” of two very important neurotransmitter systems can be postulated to work in virtually any way a psychopharmalogist might want.

But even if these trials are negative, my prediction is that this won’t stop doctors from prescribing Abilify for each of the above conditions.  Why?  Because the mechanism of Abilify allows for such elegant explanations of pathology (“we need to tune down the dopamine signal to get rid of those flashbacks” or “the serotonin 1A effect might help with your anxiety” – yes, I’ve heard both of these in the last week), that it would be anathema, at least to current psychiatric practice, not to use it in this regard.

This fact alone should lead us to ask what this says about psychiatry as a whole.  The fact that one drug is prescribed so widely—owing to its relatively nonspecific effects and a good deal of creative psychopharmacology on the part of doctors like me—and is so broadly accepted by patients, should call into question our hypotheses about the pathophysiology of mental illness, and how psychiatric disorders are distinguished from one another.  It should challenge our theories of neurotransmitters and receptors and how their interactions underlie specific symptoms.  And it should give us reason to question whether the “stories” we tell ourselves and our patients carry more weight than the medications we prescribe.

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150 Responses to How Abilify Works, And Why It Matters

  1. Rob Lindeman says:

    The word that comes to mind is “panacea”. Thank God we found it! Lord knows we’ve been looking long enough!

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  2. doctorz says:

    Steve, is that really how a partial agonist works? My understanding is that while working as an antagonist, a partial agonist allows some permeability, perhaps in the case of Abilify, as much as 15%, of endogenous dopamine for agonist binding at its receptor. So if Abilify theoretically is prescribed at a high enough dosage to saturate all of the D-2 receptors, the net antagonist effect would be 85% instead of 100%, as with other antipsychotics. This may explain why EPS can still occur since, per PET imaging studies, movement disorders are associated with D-2 binding above 80%. My question is, how would that be different than using other antipsychotics at dosages below that threshhold level? Incidentally, when I was in my training, I remember being advised by attendings to push the antipsychotic dosage gradually until EPS occurred, then back off the dosage about 10 to 15% to arrive at the maintenance dosage. It would seem that subsequent PET studies have affirmed that clinical pearl.

    • stevebMD says:

      doctorz,

      I don’t think it’s as linear as that. Remember that if you saturate all the D2 receptors with a partial agonist, you’re still giving quite a bit of a dopaminergic effect, particularly in the nigrostriatal system, which would make your 85% antagonism argument moot, even if it’s pharmacologically accurate.

      Even Stahl’s most recent writings (there’s one in particular from J Clin Psych in the last year.. I’ll find it and post it here) are gently backing off on Abilify’s role as an antipsychotic and instead proposing its use for other (perhaps more marketable?) diagnoses, playing up its role as a dopamine agonist that’s “not too much” of a dopamine agonist.

      • AntiPReality says:

        Aripiprazole blocks 75% of D2 neurotransmission at max dose.

        It was compared to Haliperidol which blocks 100% of D2 neurotransmission at max dose.

        Abilify is an INCOMPLETE D2 blocker, not a “partial agonist”. It can reduce the executive function of the brain to 1/4 performance.

        Pretty much reduces patients to coach potatoes. Not completely disabled, but not too functional either.

  3. Carol Levy says:

    I don’t know about the doctors but I would think one of the reasons for it being so “accepted’ by patients is because Pharma has done such a great job with their selling of it, and what a wonderful panaceae it is, with their advertisements on TV.

  4. Tom says:

    The fact of the matter is that the curative agents in psychiatry are non-specific. I have no idea what that means. But it is weird.

  5. dinah says:

    Thanks for this, Steve.
    Why don’t we see DrZ on Shrink Rap?

  6. stephany says:

    I wrote a blog post showing how Abilify has been marketed via phone booth ad (see the photo I took) for bipolar, to add-on antidepressant ads in magazines. Obviously, Abilify maker BMS is out to make their drug profitable as long as patent-possible.

    http://bipolarsoupkitchen-stephany.blogspot.com/2010/05/abilify-antipsychotic-turned.html

  7. Jon says:

    Abilify almost killed me. I had a muscle spasms from so severe that it broke two discs in my lower back and dislocated two others. Abilify is POISON. Do not let you or anyone else take it if you can. I can NEVER run again because of ABILIFY! and I’m only 43.

    • mike says:

      hi jon. can you tell me more about your experience with abilify. I also have had a very bad experience. thanks. mike. michaeljo720@gmail.com

    • merilyn says:

      How much were you taking?

    • george says:

      yes I agree it is poison,but im being forced to take it by my doctor and they use the courts to do it.I am trying to get a suit against them,and take them to court,so I can stop using it,and the psychiatrists,and pharmaceutical companies make a fortune,it should be banned like many other drugs,it is a viscious cirlcle,its bullshit.

      • Andrew says:

        just fill the rx and then dumb it down the toilet and nod your head and smile when they ask you if you’re taking it

    • george says:

      And im experiencing side effects such as tiredness,stiffness,constant feeling,of movement,just the thought of taking this poison is mentally disturbing,doctors can tell you you are schizophrenic,manic,anything,to keep there jobs going forever,when you get in touch with god you feel many things that are different and unusual,many people experienced this,to me the whole world is manic depressive,highs and lows.would anyone joing me for a class action lawsuit,but im in Canada.

      • tracey says:

        george i’m on abilfy. I’d join you for a lawsut mate but i’m in the uk. I’ve been researching aripriprozole tonight and i agree. it’s bloody poison

      • B says:

        I hate to hear so many negative experiences with Abilify. I have schizophrenia paranoid type and generalized anxiety disorder. Its greatly reduced the symptoms of both. I take Abilify Maintena 400mg which is a once monthly injection. My symptoms are not gone but the voices are much fainter and my paranoia is nothing like what it used to be. I also take Seroquel 100mg and Prozac 60mg. I don’t have any of the side effects mentioned here. I really hope someone researching Abilify doesn’t get scared off by reading what’s written here. My quality of life is greatly improved and I’m not like a zombie at all. Give it a try – especially the injection. Less pills to take and way more convenient. Just came upon this page and wanted to give another perspective on the drug.

    • D from the border says:

      Wow. I’m saddened by your experience and of course your end result. I tried seroquel and immediately I was restless and an half an hour later began experiencing neck and upper back muscle spasms( i have low back injury). I immediately called the dr and explained all i went through. I mean come on even my family was asking if i was on illegal drugs due to the side effects. The docs answer was o u just had a panic attack and completely disregarded the neck stiffness and spasms. This was his answer- ok ill give u buspar and abilify. So now afternoon yours and others reviews im worried about it happening again or causing some issue for which I will have to be hospitalized or causing permanent damage. Im about your age and now extremely worried as to pick up prescription or simply refuse this med. Thanks your review was exactlywhat i was looking for. By they how are u now?

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  9. Armstrong says:

    Abilify has worked wonders for my depression, OCD, and tourett’s. I’ve been on 30 different medications. Mg. for mg., Abilify is one of the most potent AAP I have been on. Keep the dose as low as possible. I take 2 mg.

  10. mike says:

    abilify (aripiprazole ) was accidentally prescribed to me in 2010. Doctors I went to, have since been shocked as to how this could have been prescribed to me. After 6 months of use it had completely poisoned me and I am now impotent and cannot have kids. Also there is pain every time I use the restroom (in my genital area) Urination / going to pee in restroom is painful most every time. It gave me a problem called pssd, which is a severe reproductive problem and I am now impotent and cannot have kids. As the above person also stated it is a poison. If you value your life and the life of your kids and any friends you have, stay clear of this dangerous and criminal medication.

    • Adele Rengaw says:

      I found this to be the most simple , yet eloquent, dignifying explanation of Abilify I have yet to find!!! BRAVO. All the pamphlets do is “SAY, DO DO THIS, THIS MAY Happen or DEATH MAY FOLLOW. I AM SICK TO DEATH OF THESE LAMEEO DISCLAIMERS!!!!! WHEN WILL THEY AT LAST GIVE BENEFITS OF THE GREAT DRUG. I SAY , THANK U SIR.

      Maybe u had an std you , ingrate. If you are unintelligent enough to state that when u have to relieve yourself, it is in your genital area, then u are not even close to making an appropriate analysis of the properties of Abilify. Perhaps u should consider the company you keep. Abilify is not to blame for for indiscretions.

      • ryleysatompkins says:

        You fucking dick, he was clarifying because it could have been abdominal pain for all you fucking know.

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  18. Cody says:

    Abilify has really “leveled” me out so to speak. I definitely don’t feel like I have the energy that I used to have. I’m actually going to stop taking it tomorrow. I’m taking Ativan for extreme anxiety but Abilify at 5 mg just seems too much for me to handle. I definitely don’t have the drive that I used to have. My testosterone levels and everything are fine, they were checked… so I know it’s not anything else causing me to feel this way. I’m gonna stop taking Abilify and tell my doctor that I’m going to as well. Maybe I can get on some type of SRII instead of Abilify, because I think it would work better in my case. I got 2 different psychiatric evaluations from 2 different psychiatrists. The first psychiatrist evaluated me and said I needed more serotonin and I told the 2nd psychiatrist that I have a history of going from extremely low to extremely high (bipolar). In my case though I’d rather go back to being bipolar than to be leveled out all the time. It just sucks feeling like a coach potato all the time especially when I was such an active individual. I wouldn’t recommend Abilify to anyone who is a very active person. I don’t know about a very small dose but the dose I’m taking at 5 mg is just too much leveling for me.

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  79. Jason says:

    All I can say about this drug was that it caused severe akathisia, which was so uncomfortable I was crying for hours each day until I stopped. I could only tolerate about a week of that. I prefer Depakote any day, and low dose seroquel at night. Seroquel is so much milder, even though it causes sedation and weight gain, it actually has a really pleasant calming effect. In fact, seroquel is a drug of abuse in some places. Don’t prescribe just based on pharmacology. Listen to your patients!

  80. […] How Abilify Works, And Why It Matters | Thought Broadcast – One lament of many in the mental health profession (psychiatrists and pharmascolds alike) is that we really don’t know enough about how our drugs work…. […]

  81. Frank Kecskes says:

    Why do we always seem to treat the symptoms but not the caus? What factors cause the the all inclusive “chemical imbalance” in the brain? Until we come to that understanding, we will be spending our resources on drug after drug and still not getting at the root of the cause. We need a Dr. Ornish approach to getting at the cause.

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  89. Adele Rengaw says:

    All the comments of receptors, agonists and the such make me sick!! The good doctor’s explanation is broken down well enough that anyone with mental illness that is truly informed about their illness , can understand it. I learned a long time ago, “Knowledge is Power”. Always on every drug, there are the warning signs , and the classifications, thereof. NEVER IN MY 20 YEARS OF BEING DIAGNOSED HAVE I EVER SEEN AN EXPLANATION, TELLING HOW THE DRUG HELPS
    Abililify will not grow back a leg , cure diabetes, but like Plavix made such a positive contribution to so many persons’ health recovery, WHY should anyone with half a brain ( and I use that loosely) argue over minute details? Must we thrown out the baby with the bathwater? If it is too expensive, appeal, make a case with knowledge, not anger n emotion to your insurance company. They will listen. I did for my husband, backed by his doctor, we won!!! Or Bristol Meyers will be glad to help. Use KNOWLEDGE TO EDUCATE, DONT BERATE THE MAKERS OF THIS WONDERFUL, LIFE SAVING PRODUCT.

  90. Helen says:

    My mother was on ability for a while. She paced all day, slowly, unable to control her feet. They were always gently tapping. Everything she did was in VERY SLOW MOTION, except the tap. When she told her psychiatrist, he informed her, she was in her 70’s and “slow” was normal. She was in an internal hell.
    I went with her on her next visit to validate that her speed was quite peculiar to her personality and physical ability. He took her off of it.
    She often tries to recounts the story of ability hell, from which I distract her ASAP, so as to keep her from the place that brought her to being prescribed it in the first place.

  91. Helen says:

    But what brought me to this site today…is one of my neighbors invited me into her home today. She’s an odd sort of soul with a longing look in her eye, if you catch her eye. She paces up and down the street, very slowly, sort of searching. She looks to be concentrating on putting her feet in front of her, like it takes a concentrated effort to place them in the right spot. Yet, she is always walking.
    While I was there, her mother asked her if she had taken her abilify.
    I am not a psychologist or a psychiatrist, but I recognize the behavior.

  92. Helen says:

    Hello. Posting in because I forgot to check “notify me of new posts” the first two times. Looking forward to hearing from you.

  93. Ben b says:

    Hi,
    Thanks for the great post.

    I have a q I’d be keen to hear your thoughts on: If someone has been diagnosed ONLY with major depressive disorder, why would Abilify be prescribed when it is to be used as an adjunct to an existing antidepressant (not instead of). Misinformed psych doc perhaps?

    Look forward to hearing your thoughts.

    Thanks

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  95. Mark Dubois says:

    I’ve been taking Abilify and so far, having started on 5 mg’s and moving up to 10 mg’s, have seen a difference from taking nothing for my schizophrenia, to some improvement, to drastic improvement.

    Soon (within a week or two) I will try out 15mg’s. It is thought I will make a full recovery from my symptoms which is the most important thing for me. Having side effects and the possibility of not being able to be having sex, or being restless, or moving consistently, is secondary to having the framework where my mind lets me have the opportunity to live decently. Not that ED is decent, but who gets laid when they’re hearing voices and are freaking everybody out because of their reactions to hallucinations. I guess its time to look at this using a Bayesian reasoning model on a case by case basis like Dr. Daniel Leviten suggests medical practitioners do. For me its logical, and there’s only one way to know what side effects will affect whom, and that’s to try it. I’m sorry if this (Abilify) isn’t the answer for you, but the answer is still out there, with side effects of their own to deal with.

  96. Shawn says:

    Abilify was nasty all it did was make me want to march back and forth in place and it made me more agitated. I even did this out in public with the pacing back in forth. They call it akathisia.

  97. Shawn says:

    The funny part is that I didn’t even know I was doing it.

  98. Helen says:

    The marching back and forth is so sad, I feel like asking very pacer if they are taking abilify.
    It can also cause a parkinson effect.

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  100. […] I still have weird feelings about feeling more alive on antidepressants. What it really means is that I have NO CLUE about how depression affects the brain. I’ve been reading and asking questions. It’s hard to absorb information on neurotransmitters and such, but I now understand that how I feel without antidepressants is a part of my brain not functioning properly. How I feel with Abilify and Lexapro means it’s making my brain work properly. I promise that when I can explain this in layman’s terms, you’ll be the second to know, lol. I am researching and gathering information, like this blog. […]

  101. T.brown says:

    Abilify really helped me I am less hindered by my depression and overeating

  102. Kent says:

    Just about to start on 15mg Abilify for Bipolar II Disorder. I’m in my mid 50s and have been through many med combos including Lithium, Depakote, most of the anti-anxiety meds and the anti-depressants. No combination has given me the relief I seek. Lithium came close but the side effects were unbearable. The worst part of bipolar is the mania. It’s so destructive and scary that I’d do nearly anything to be rid of it. Suicide has always been a plan, but somehow I’ve managed to escape a full on attempt. I’m hopeful that Abilify will level me out. I don’t mind the couch potato effect as long as I can work and remain alert. Ironically, I’m a pharmacy technician. I’ve seen more vicarious success from Abilify than most other alternatives.

    Thanks for this insight and your observations. Here’s hoping it works for me, I’m tired of wishing I could feel stable and look forward to some relief.

  103. Excellent article! I think you pose a great question, and I thank you for this concise and well written edification on Abilfy.

  104. Paul Clark says:

    I used Abilify 2 to 4 mg per day) from 2008 to 2015 as an addition to Cymbalta (120 mg per day). it really calmed me down and made me less irritable and angry and even helped me have a somewhat not depressed mood. It allowed me to have enough energy to do mental work and also get along with my family and make and keep some friends.

    However my weight with a height of 5 foot 11 was 230 in 2008 and I think with the increase in appetite from Abilify my weight increased to 250 in 2010 to 2012 and was at 260 lbs in 2013-2014. In 2015 I am 278 lbs. My triglycerides are high at about 300 and my overall cholesterol is in the 220 or 230.

    I am trying to get off of it by taking just my Cymbalta 120 mg and 150 mg of Wellbutrin. But Im experiencing fatigue. But I guess that is better than severe obesity.

    There are too many risks for obesity

    I have been adjusting my medications with just taking Cymbalta and Wellbutrin and no ability. Wish me luck I have the same energy and I don’t get depressed.

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  106. I’ve been taking 2mg abilify for 2 weeks now after I felty major depression slowly getting worse, lack of energy, sleeping more, and irritability. It’s worked well in combo with pristiq (which Ive been on for 3 months now after switching from Effexor)

    My question is can this med be taken as needed?

    I feel better now and I’m actually exercising more (didn’t feel like it before but since adding abilify I’m more motivated to wake up early and workout) which is helping my mood.

    I’m planning on asking my bed managent doctor but I wanted to see if anyone has taken this as needed say for seasonal depression or for a short time.

  107. I’ve been taking 2mg abilify for 2 weeks now after I felt my major depression slowly getting worse, lack of energy, sleeping more, and irritability. It’s worked well in combo with pristiq (which Ive been on for 3 months now after switching from Effexor)

    My question is can this med be taken as needed?

    I feel better now and I’m actually exercising more (didn’t feel like it before but since adding abilify I’m more motivated to wake up early and workout) which is helping my mood.

    I’m planning on asking my med managent doctor but I wanted to see if anyone has taken this as needed say for seasonal depression or for a short time.

  108. Kjf says:

    would you prescribe ssri’s to patients who don’t believe they are any more effective than a placebo?

  109. Eileen mcdonald says:

    What time of day should ability be taken?

  110. […] I was in the hospital, they lowered my Abilify dose and a few days later it was a disaster. I really need to be on the dose I am now and just deal […]

  111. […] Balt, S. (n.d.). How Abilify Works and Why It Matters. Retrieved from https://thoughtbroadcast.com/2011/09/13/how-abilify-works-and-why-it-matters/ […]

  112. Al says:

    Hello,

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  113. […] September 13). How Abilify works, and why it matters. The Carlat Psychiatry Report. Retrieved from How Abilify Works, And Why It Matters National Alliance on Mental Illness (NAMI). (2014). Second generation antipsychotic medication […]

  114. Rodger says:

    Do not under any circumstances take this drug. I was forced to take this drug after being directed with energy weapons, what is commonly termed as mind control using directed electronic weaponry. The doctors could not comprehend mind control as a true reality so forced my trousers down to inject this drug into me. If i refused to take this drug they would rape me with needles. I am still suffering with the aftereffects of taking this drug up to 4 years on. I mainly have sudden urges of restlessness and know my body well, this is an after effect of taking this drug previously in my life.

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  117. Heather says:

    I took Abilify for about 4 months. It was great!! I felt better, more stable… Then I had a lipid profile. My triglicerides were over 2000. They should be under 200. They were about 350 when I started which was high but no where near 2000. After stopping they reduced in half. I just got a call from the nurse and they are about a thousand. Triglycerides are the #1 indicator of heart disease btw for those who are unaware of this fact.

  118. Caitlin Scofield says:

    This was very clearly written and extremely helpful. Thank you.

  119. Anna says:

    I have been on abilify for about two weeks now and I didn’t realize how really depressed I was both mentally and physically. Meds work differently for everyone but luckily I have had great results with no side effects. I have more energy and motivation to get things done and do things that I enjoy. I’m on 20 mgs along with 300 Wellbutrin and 60 cymbalta. Good luck to you all

  120. Karen Meys says:

    My grandma had Parkinson’s disease, she is about 80 years old it was detected 7 years ago. Right now it’s getting more difficult to live for her, because of stiff muscles she can’t even move. L-dopa and carbidopa medicines are given, but won”t give much relief. She can”t eat food and the skin is damaging forming ganglia. This is may be the last stage of disease.. nothing was really working to help her condition. Finally she started on parkinson’s herbal formula i purchased from Health Herbal Clinic, i read alot of positive reviews from other patients who used the parkinson’s herbal treatment. she used the herbal remedy for 7 weeks, its effects on parkinson’s is amazing, all her symptoms gradually faded away, she feed very more freely by herself now! I recommend this parkinson’s herbal formula for all Parkinson’s Patients.

  121. Anony Mous says:

    Depression tends to run in families, which major depressive disorder
    may bolster the theory that chemical imbalances are somehow involved. However, social and psychological problems may also be suspect, the result of child abuse, neglect, severe marital conflict or divorce, death of a parent, or other familial disturbances may also contribute to the onset of depression.

  122. Julia Ford says:

    I’ve experienced everyone of the side meffects it has devastated my life in the 6 months I was on it. I also lost more than 20 lbs. my liver is elevated my liver count I have TD. I had that cold and had to go to the hospital and get an inhaler. I impulsively tried to commit suicide

  123. Anon1 says:

    Can anyone offer any thoughts on being on 10mg abilify with 50mg amisulpride? I believe I am overmedicated but was told that these were very low doses.

  124. My husband is 80 years and has been suffering from PD for the past 15 years. Lately he started hallucinating and I didn’t know how to handle the situation. He cannot sleep and tried to find and catch the imaginary people who he thinks are real. he was taken Entacapone with Levodopa, Carbidopa, and Pramipexole and started physical therapy to strengthen muscles. nothing was really working to help his condition.I took him off the Siferol (with the doctor’s knowledge) and started him on parkinson’s herbal formula i ordered from Health Herbal Clinic, his symptoms totally declined over a 5 weeks use of the Parkinsons disease natural herbal formula.i read reviews from other previous patients who used the herbal formula, my husband is now active, he can now go about daily exercise!! his symptoms so much reduced that now I hardly notice them.

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  128. rileyaria says:

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  129. Abigail lkhuenbor says:

    Hope abilify does not stop fertility

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